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Furthermore, defects in IFN- signaling, often due to loss-of-function mutations in JAK1/2 or STAT1, impair human leukocyte antigen (HLA) upregulation, diminish PD-L1 expression and impede T-cellmediated antitumor responses, thereby conferring resistance to ICB

Within months, demand exceeded supply, and compounding pharmacies began providing access to those facing shortages or seeking more affordable alternatives through licensed 503A compounding channels

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