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With no plateau in sight the weight-loss curves were still trending downward when the study ended

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Similarly, using multiple compounds that all increase serotonin (Pinealon plus high-dose 5-HTP plus an SSRI, for example) could theoretically create excessive serotonergic activity

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Cagrilintide showed similar directional improvements, though the magnitude was generally proportional to the degree of weight loss rather than suggesting independent cardiovascular effects