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4.2.6 Possible important contextual details pertaining to the study design and/or analysis The PICOS study design: This study does not have any perceivable adverse contextual details regarding the study design as this is a systematic review and a meta-analysis based on the Cochrane Organisation template for systematic review and meta-analyses

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It differs from native IGF-1 at two positions: a 13-amino-acid N-terminal extension and substitution of arginine for glutamate at position 3

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