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b , 3D representation of the MMGBSA energetically Representative MD frame at 47 ns of simulation

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Inhibition of GR disrupts the GSH/GSSG balance, leading to the accumulation of ROS and subsequent oxidative damage beyond the repair capability of the bacterium

By integrating these strategies with structure-guided design and SAR analysis, dual inhibition emerges as a promising avenue for schizophrenia treatment

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