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The result can include increased oxidative stress, inflammation, and cellular damage

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Crit Rev Biotechnol 30:161175

Wei R, Zhao Y, Wang J, Yang X, Li S, Wang Y, et al

Ferroptosis activation in TGF--treated HK-2 cells is suppressed by GPX4 overexpression Our in vivo studies revealed the role of GPX4 overexpression in attenuating TEC ferroptosis and fibrotic changes during UUO

In terms of vascular function regulation, chitosan nanoparticles loaded with nitroglycerin (TNG-CNPs) release NO in a sustained manner, activating the guanylate cyclase-cGMP pathway, significantly inhibiting NADPH oxidase activity, and simultaneously enhancing eNOS activity, thereby alleviating microvascular spasm