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Therefore, mutations in the PLPBP gene disrupt this process, causing PLP to react with other substrates and impacting the metabolism of important amine or amino acid neurotransmitters in the brain, consequently leading to the development of epilepsy
J Clin Endocrinol Metab 57:662664 Rasschaert J, Malaisse-Lagae F, Sener A, Leclercq-Meyer V, Herberg L, Malaisse WJ (1994) Impaired FAD-glycerophosphate dehydrogenase activity in islet and liver homogenates of fa/fa rats
