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doi: 10.3389/fcell.2025.1489959 Received 02 September 2024 Accepted 24 January 2025 Published 20 March 2025 Volume 13 - 2025 Edited by Fredrick Rosario-Joseph, University of Colorado Denver, United States Reviewed by Pedro A

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Detox pathways (biochemistry): Glutathione participates in conjugation and detoxification reactions in the liver

152 Potential mechanisms for this action are suppression of cholesterol synthesis by inhibition of the HMG-CoA reductase enzyme or an increase in the rate of LDL degradation

Graphical abstract This graphical abstract illustrates the diverse therapeutic capabilities of hesperidin, which operates through the modulation of oxidative stress, inflammation, apoptosis, and various metabolic pathways