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The genie is already out of the bottle

For instance, in November 2023, results from the SELECT trial published in the New England Journal of Medicine showed that once-weekly semaglutide 2.4 mg reduced the risk of major adverse cardiovascular events by 20% in adults with overweight or obesity and established cardiovascular disease without diabetes, highlighting the expanding role of long-acting GLP-1 analogues beyond glycemic control into cardiovascular risk reduction

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PSCs express desmin and glial fibrillary acidic protein (GFAP) specifically in pancreas [9]

For example, obese diabetics are a special case and should not be given the full mortality and morbidity benefit for the weight-loss indication in addition to the diabetes indication

Moreover, GLP-1RAs can alleviate vascular remodeling expressed as neointimal hyperplasia after induced vascular injury