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It facilitates the formation of multivesicular bodies (MVBs) and exosomes containing iron-rich proteins, allowing the removal of excess intracellular iron via these exosomes, thus preventing cellular ferroptosis
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Table 1 List of Bioactive compounds and mechanisms in MetS
A ruptured plaque can trigger a blood clot that blocks blood flow, potentially causing a heart attack or ischemic stroke
Soucek L, Evan GI
826 Downregulation of Panx1 significantly reduces ferroptosis and iron accumulation in renal cells induced by erastin, through inducing HO-1 expression and the mitogen-activated protein kinase (MAPK)/ERK pathway
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