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The SELECT trial (2023) demonstrated that Wegovy significantly reduces major adverse cardiovascular events (MACE) heart attack, stroke, cardiovascular death in patients with established cardiovascular disease and obesity
Chung S, Hsia D, Chacko S, Rodriguez L, Haymond M (2015) Increased gluconeogenesis in youth with newly diagnosed type 2 diabetes
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Common mutations in p53, including missense, nonsense, and frameshift mutations, can increase the proteins half-life, leading to the accumulation of dysfunctional mutant p53 that impairs normal tumour-suppressive functions (37, 38)
Similar to medical conditions such as diabetes, weight loss goals are personal
At the same time, the review notes that higher dosages, for example from 4 grams per day, can increase total cholesterol and LDL cholesterol in some studies
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