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In response to growing criticism of the cost of their drugs, Novo Nordisk, the company that manufactures Ozempic and Wegovy, reported last year that rebates and other fees (across all payers) accounted for about 40% of the cost of the two drugs and that they expected rebates to grow
PMID: 131 DinhDTRussellDL
The following diagram, which begins with the results of terminal unit analysis, illustrates the logical steps that could be used to solve the structural problem
According to research principles: Clinical trial results represent average outcomes under ideal conditions with: Highly selected participants (extensive exclusion criteria) Monthly professional monitoring and support Free medication (eliminates cost barriers) Structured lifestyle interventions High adherence rates Real-world results may differ due to: Variable medication adherence Different lifestyle modification levels Varying dose levels reached Cost/access barriers affecting consistency Less frequent monitoring Individual metabolic differences Some individuals exceed clinical trial results
This is particularly concerning for older adults or those with kidney disease
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