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According to the review, [GLP-1 receptor] signaling in astrocytes regulates both central and peripheral metabolism, extending from energy balance to neuroplasticity. This signaling also enhances neuron growth, and an increase in astrocytes also increases neuron survival

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These findings have led to the inclusion of GLP-1 receptor agonists in updated treatment guidelines by organizations like the American Heart Association (AHA) and the American Diabetes Association (ADA) for patients with these comorbidities

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