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Research has shown that metformin can block the reabsorption of bile acids by reducing the levels of Na + -dependent bile acid transporter proteins and controlling the function of farnesoid X receptor (FXR) (Lien et al., 2014
Semaglutide: Focuses on one primary pathway (GLP-1)
According to clinical trial data from the STEP trials, 43.9% of patients taking semaglutide 2.4 mg experienced nausea at some point during treatment, with the majority of episodes occurring during or immediately after dose increases
Nausea is also more common in the first few weeks of treatment
But it is not guaranteed
Don't hesitate to reach out to your provider if you: Have been taking semaglutide for several months without seeing significant weight loss progress
