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HS218 as an FXR antagonist suppresses gluconeogenesis by inhibiting FXR binding to PGC-1alpha promoter
Before the first use, they must remain in the refrigerator
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Patients with proliferative retinopathy should be referred for treatment according to standards of care established by pivotal studies such as the Diabetic Retinopathy Study, the ETDRS, and the Diabetic Retinopathy Clinical Research Network (DRCR) Protocol S ( Figure 1 )
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Effective contraception is essential during treatment, as these medications are contraindicated in pregnancy, with a recommended washout period (approximately 2 months for semaglutide) before planned conception
