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Day-WalshPShehataESahaSSavvaGMNemeckovaBSperanzaJet al
In a series of experiments in monkeys with obesity and diabetes, the tri-agonist SAR441255 showed superior metabolic outcomes to that achieved with a comparator dual GLP-1/GCG RA
No human study has established a route conversion or shown that they match oral exposure
It puts headache incidence in the range of 5 to 15 percent across GLP-1 trial populations
Guerri C, et al
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