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The market for semaglutide API is expanding as long as regulatory agencies continue to encourage novel therapies for diabetes and obesity

The antihyperglycaemic effect starts after the first dose and is sustained throughout the once-weekly dosing interval, as a result of the prolonged half-life of 4.7 days

These symptoms usually occur early in treatment and tend to improve over time as the body adjusts to the medication

In a study of 80 obese people with type 2 diabetes receiving semaglutide and dulaglutide, a 20% reduction in the thickness of EAT was observed (62) One meta-analysis demonstrated the cardioprotective effects of GLP-1 RAs, showing reductions in blood pressure and lipid profile, with a significant increase in HDL levels (63)

For every kilogram of body weight lost, triglycerides typically decrease and HDL cholesterol increases