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15,4244 Naringin enhances mitochondrial membrane potential and decreases reactive oxygen species levels, helping to improve insulin resistance

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*Indicates a statistically significant difference compared with the Normal group

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Moreover, tumour cells crosslink the CAFs derived from Col1 fibres in the TME by upregulating Lox, leading to a stiffer Col1 matrix, which promotes tumour cell motility and progression [185] (Fig

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