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2018 Aug 1;39(4):489-517
The peptide typically remains stable for 30-45 days when refrigerated
Its pharmacological interest is as an inhibitor of nicotinamide N-methyltransferase, usually written NNMT
Users should not expect the appetite reduction that comes with compounds like semaglutide or tirzepatide
Reduced NNMT in adipose tissue was associated with increased expression of polyamine flux genes and increased adipocyte energy expenditure connecting NNMT inhibition to "futile cycling" mechanisms that consume energy without productive metabolic output
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