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By antagonism of central 2 -adrenergic heteroreceptors and autoreceptors as well as postsynaptic inhibition of 5-HT2 and 5-HT3 receptors, MTZ increases noradrenergic and 5-HT1A-mediated serotonergic neurotransmission (Fig

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In the liver, a particular metabolic pathway called transsulfuration permits the supply of cysteine by conversion of an essential amino acid: methionine

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