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The first drugs that came in (like guanethidine) had horrible, terrible side effects
The pharmacokinetic profile appears to support sustained receptor engagement throughout the weekly dosing interval
A high conversion rate of choline into methylamines, such as TMAO, decreased choline levels and causes fatty liver disease in mice [35]
Research suggests the anabolic ceiling for most individuals occurs around 40-50 mcg/day (Philippou et al., 2007)
A dosage change may be needed if blood sugar remains high, weight loss has stalled, or side effects are interfering with daily life
The most important management strategy is patience
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