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Safety : Generally safe when administered by professionals, with mild and temporary side effects like injection-site irritation

In combination with pioglitazone, Januvia provided significant improvements in A1C and FPG compared to placebo with pioglitazone (Table 7)

Patients should use a different location for each injection and avoid skin that is bruised, red, swollen, tender, scarred, hardened, infected, or otherwise irritated

Never shake the vial as this can damage the peptide structure

Neuropharmacology (2014) 76:5767

Smaller, more frequent doses can smooth out the peaks and troughs of drug levels, potentially reducing the post-injection side effect spike while maintaining consistent appetite suppression throughout the week