The table lists five: fasting insulin above 12 mIU/L, an HbA1c trend within the 5.7 to 6.4% band, BMI trajectory, family history of type 2 diabetes in a first-degree relative, and inflammatory markers such as CRP and IL-6
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Most of these interventions are also highly debated
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While other reviews have described the MACE risk reduction in the general population with T2DM [23, 24], non-T2DM [25], or both [26], the present study seeks to address the gap in the literature in providing a comprehensive meta-analysis on the number need to treat (NNT), efficacy and safety profile of GLP-1RA in reducing the risk of myocardial infarction (MI) and individual ASCVD constituents, namely non-fatal MI, unstable angina, coronary revascularization, and/or cardiovascular mortality
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