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Chronic hyperglycemia accelerates all complications via oxidative stress, advanced glycation end products (AGEs), and the polyol pathway
Chronic systemic inflammation is also associated with elevated lipolysis in white adipose tissue and lipogenesis in nonadipose tissues, causing ectopic fat deposition in nonadipose tissues and imbalance in free fatty acid homeostasis and increased risk of IR [63]
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Tesamorelin Studies in patients with HIV using tesamorelin have shown that this peptide increases lean tissue mass while reducing fat accumulation, particularly in abdominal regions, says Roberts
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