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The mean differences in A1c and body weight between IDegLira and basalbolus therapy and IDeglira and basal glargine were 0.3% and 6.89 kg and 0.65% and 4.04 kg respectively

A proportion of participants in the retatrutide trial discontinued treatment due to gastrointestinal side effects that did not resolve

Wessells H et al

Peer review Peer review information Nature Aging thanks Christian Hlscher, Tami Rubinek and Marc Schneeberger for their contribution to the peer review of this work