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Mechanism of Action: Morphine acts on (mu) opioid receptors in the CNS and produces analgesia by: Activating G-protein coupled receptors Opening K channels hyperpolarization of neurons Closing Ca channels reduced neurotransmitter release Decreasing release of pain mediators like substance P and glutamate Results in Pain signal transmission in brain and spinal cord strong analgesia

The stability testing, if conducted at all, covers a fraction of the timeframe that Eli Lilly studies

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Buteau, J., Foisy, S., Joly, E

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Longer protocols may produce greater results as more follicle cycles complete