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Contraindications include: Sulfa allergy, due to potential sensitivity to methionine derivatives
H., Shenvi, S
whether an analogous risk attends cagrilintide in insulin-treated populations has not been established, since the trials excluded or did not focus on that group
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Specifically, SIRT3 deacetylates and inhibits aldehyde dehydrogenase 2, which prevents the conversion of acetaldehyde to acetate, potentially leading to acetaldehyde toxicity 183
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