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There is no clinical trial data specifically studying this approach, but some prescribers report anecdotally that patients maintain better long-term responses with periodic dose reductions

A meta-analysis of various studies found that topical Vitamin C can significantly reduce melanin production and improve skin brightness

For example, nausea occurred for 173 patients on 5mg, 237 patients on 10mg, and 283 patients on 15mg

(PDF) Krystal, A.D., Pizzagalli, D.A., Mathew, S.J., Sanacora, G., Keefe, R., Song, A., Calabrese, J., Goddard, A., Goodman, W., Lisanby, S.H., Smoski, M., Weiner, R., Iosifescu, D., Nurnberger, J., Szabo, S., Murrough, J., Shekhar, A., Potter, W

Tri-Fortify also overcomes the off-putting taste found with most other glutathione supplements

Using glutathione products can give you healthy, smooth and elastic skin