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Furthermore, studies using a peripherally administered exenatide analogue conjugated to vitamin B12, which is sterically hindered from accessing regions protected by the blood brain barrier, improves glucose control in comparable fashion to unmodified exenatide, presumably at the level of the -cell, but does not induce emesis in the house musk shrew ( Suncus murinus) or rats (78, 79)
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In addiction treatment settings specifically, patients have generally tolerated the medications well, and clinicians have reported no unexpected or severe adverse effects
Additional safety considerations include risk of dehydration and acute kidney injury, potential worsening of diabetic retinopathy with rapid glucose improvement (particularly with semaglutide), and hypoglycemia risk when combined with insulin or sulfonylureas
Most importantly, journals have becoming more attentive to signs of potential fraud
A: You should not stop taking semaglutide without talking to your healthcare provider
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