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The need for neuroprotection in HD is particularly urgent given the protracted presymptomatic phase, during which subtle cognitive and psychiatric changes may precede overt motor symptoms by years

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These mice also exhibit abnormal neurotransmission in brain regions associated with cognitive and social functions

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Researchers are not exactly sure what the mechanism is, but common triggers for telogen effluvium may include: a serious or chronic, debilitating illness or infection major physical trauma childbirth major surgery high fever hormone imbalances (like low or high thyroid) or androgen excess rapid or extreme weight loss nutritional or vitamin deficiencies that require supplementation (iron, zinc, vitamin D deficiency) psychological or emotional stress certain medications Nutritional deficiencies, low protein or caloric intake and a sudden change in eating habits can worsen the possibility of hair shedding due to rapid weight loss with these medications