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This synergistic combination is why it outperformed earlier GLP-1 monotherapies like semaglutide
With Ozempic, the trials showed an average weight loss of 6% over one year
GLP-1RAs, SGLT2is and dipeptidylpeptidase-4 inhibitors (DPP4is), with early combination therapy advocated when the patients HbA 1c is above target despite diet, exercise and metformin [5, 6]
Serious problems are rare but should be watched for
Key takeaways Mounjaro (tirzepatide) and Ozempic (semaglutide) are similar GLP-1 medications that are FDA-approved to treat type 2 diabetes
based on Valdecantos 2024 sub-max data Taper tirzepatide at the end of a cycle rather than stopping suddenly
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