The two co-primary endpoints were analyzed independently, requiring statistical superiority for both to demonstrate a significant benefit of semaglutide versus placebo
History of ulcers or GI bleeding: If you have had a stomach ulcer in the past, NSAIDs are generally discouraged
Reduced Physical Activity Reduced caloric intake on GLP-1 medications sometimes comes alongside reduced physical activity, either because fatigue is a factor in the early weeks or because lower energy availability makes exercise feel harder
Supplements can be a helpful addition if were not getting enough of certain nutrients, minerals, or vitamins, but you dont have to take any unless theres a need
Some medicines can also reduce glutathione levels
Non-oral contraceptives like the IUD, implant, patch or condoms do not appear to be affected by GLP-1 use, he adds