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Unlike pure GLP-1 agonists, glucagon receptor activation can increase hepatic glucose output and may require careful monitoring in patients with diabetes
The results showed symptom relief that persisted for 2-4 months after the treatment
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Tirzepatide (Mounjaro/Zepbound), a dual GIP/GLP-1 receptor agonist, produced 20.9% mean weight loss at 72 weeks in the SURMOUNT-1 trial (N=2,539) at the 15 mg dose [10]
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The collective effect of the evolution is that the 3FTXs now appear in different isoforms with different structures and various distinct biological functions
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