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Hypothyroid patients on thyroid replacement therapy are generally safe candidates, but their endocrinologist should be notified of GLP-1 treatment initiation so TSH monitoring can be adjusted as needed
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A study evaluating the effects of liraglutide treatment in lean and obese rats on a high salt diet found improved dilatory response of microvessels to acetylcholine ( Among humans, some studies suggest an association between GLP-1 RAs and CMF, while others report no association