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high-dose oral B12 (10002000 micrograms daily) can achieve adequate absorption through passive diffusion

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2021 [cited 2024 Jul 12];6:6351

We found a dose that seems to be effective, and the dose escalation will be slowed down further as we go into the phase III trial to increase tolerability, said Robert Kushner, professor emeritus of medicine at Northwestern University and one of the co-authors of the Nature paper on aleniglipron, in a statement from the university

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Fasting insulin is a stronger and more specific predictor of hot flashes than BMI or fasting glucose