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Expected onset: Initial metabolic changes within 2-4 weeks

"Our findings should be viewed as being significant but tentative, as future studies are needed to examine these questions in a much larger and more diverse population, said Rizzo

A large systematic review published in the BMJ in 2026 found that weight regain after stopping GLP-1 medication was, on average, somewhat greater than after stopping behavioral weight-loss programs

Patients should stay informed, monitor their health closely, and maintain open communication with their healthcare providers

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This continuous support is particularly helpful during the early stages of treatment when side effects and adjustments are most common