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The extended half-life is achieved through deliberate structural modifications to the peptide backbone
Those using the medication for weight management typically have a BMI that qualifies them as obese or overweight with weight-related health conditions
Short-acting GLP-1 agonists like exenatide (taken twice daily) may produce more immediate effects on post-meal glucose levels, whilst longer-acting weekly formulations such as semaglutide or dulaglutide provide more sustained action but may take longer to reach steady-state concentrations in the body
On one hand, many doctors only recommend name-brand medications to their patients
Safety and tolerability were consistent with previous observations for sema and other GLP-1RAs
Journal of Ethnopharmacology, 161, 6981
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