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It is a synthetic analogue of alpha-melanocyte-stimulating hormone with melanocortin-receptor activity, with the page structured to help researchers identify the product, select a listed option and plan suitable controls

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A 2025 meta-analysis of four randomized controlled trials involving 27,617 participants demonstrated a 19% reduction in major adverse cardiovascular events (relative risk 0.81, 95% CI 0.74-0.88), with additional benefits for cardiovascular death and nonfatal heart attack

However, translation to human therapies requires rigorous clinical trials to establish safety and efficacy

In the hypertensive rat model, Yang et al