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In preclinical models of neurodegeneration, GLP-1R agonists reduce amyloid plaque formation, improve neuronal survival, and reduce neuroinflammation

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Rational combination therapies that simultaneously address multiple resistance pathways are likely to become increasingly important, particularly those integrating targeted agents, epigenetic modulators, metabolic inhibitors, immunotherapies, microbiome-directed interventions, and TME-reprogramming strategies

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