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the method solves the problems of difficult research on the impurities of the semaglutide, difficult purification and lower yield caused by a biological fermentation method

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Neuron 88, 553564

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Phenyl isothiocyanate was then treated with Compound 20 and afforded the pyrazolo-pyrimidinone ring-containing Compound 21 , which was treated with a substituted benzyl halide to afford Compound 22