Shay, a hepatologist who specializes in metabolic liver diseases including metabolic dysfunctionassociated steatotic liver disease (MASLD) and metabolic dysfunctionassociated steatohepatitis (MASH), noted that clinicians should consider these agents as part of a broader strategy for managing metabolic disease
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Decision points: At 8 weeks, evaluate
As phase II enzymes, GSTs detoxify chemical compounds through catalyzing nucleophilic attack by the thiol group in reduced glutathione (GSH) on a wide range of electrophilic substrates [37, 40, 41]
4 Effect of cysteine restriction on tissue GSH, serum GDF15 and FGF21 levels
Elevated lipase and amylase levels may occur, though routine monitoring of these enzymes is not recommended unless clinical symptoms suggest pancreatitis