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Small molecule GLP-1 agonists in the clinic Orally dosed small molecule receptor agonists of GLP-1R such as danuglipron, lotiglipron and orforglipron (Figure 1) have been discovered and have progressed into clinical trials
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Transitory Exhaustion
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This distinction matters enormously when considering whether rotation between them is safe, effective, or even practical
But lots of people end up stopping GLP-1s, often due to side effects or cost or thinking that they can maintain on their own without medication
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