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Leg cramps are not listed as a recognized adverse effect in FDA prescribing information for semaglutide
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Accordingly, it has several metabolic effects consistent with the actions of GLP-1 and glucagon (stimulation of insulin secretion, reduced appetite, increased energy expenditure), although whether these are important physiologically is uncertain (55)
Patients should be reassured that gastrointestinal symptoms, including belching, often improve over time as the body adjusts to semaglutide
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