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GLP-1 medications have multiple different mechanisms in the body that help with diabetes and weight loss, including: Increasing the amount of insulin made by the pancreas , which helps control blood sugar in patients with diabetes Decreasing the amount of excess sugar made by the pancreas , which helps control blood sugar in patients with diabetes Slowing down digestion from the stomach , which results in feeling full for longer after eating Signaling to your brain that you are full after eating , which helps suppress appetite and control cravings Tirzepatide contains an extra mechanism of action that other GLP-1 medications do not, known as GIP (glucose-dependent insulinotropic polypeptide) agonism

GLP-1 weight loss patients typically lose 30 to 80 pounds and often present with mild to moderate skin laxity, while bariatric surgery patients commonly lose 80 to 150-plus pounds with more severe excess skin

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Semaglutide and liraglutide effects on central nervous system regulation GLP-1 and GLP-1RA are involved in the activation of various central nervous system (CNS) processes, including satiety, thermogenesis, blood pressure, neurogenesis, and inflammation reduction (15)

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