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The mice were euthanized through CO2 inhalation when the tumor volume surpassed 1500 mm or when the mice showed signs of serious weight loss, dreadful weakness, or Unhealed ulcers, indicating they were moribund

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For hepatic impairment specifically, the evidence hierarchy places the current knowledge base at Level 5 (expert opinion and mechanistic reasoning) on the Oxford Centre for Evidence-Based Medicine scale [11]

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