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The observed outcomes were particularly significant in fibroblast-like synoviocytes, key players in RA pathogenesis, with the following main effects: (1) inhibition of NF-B nuclear translocation, leading to a decrease in the production of pro-inflammatory cytokines, including TNF, IL-6, IL-8, IL-1, MCP-1, and High Mobility Group Box (HMGB)-1, all of which are involved in RA progression

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( a ) SAD participant flow chart (CONSORT diagram)

Unregulated skin whitening capsules, skin whitening tablets, and so-called permanent skin whitening cream without side effects often contain harmful ingredients like mercury or steroids, leading to long-term skin damage

10.1016/j.physbeh.2019.03.026 Physiol