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Current clinical management primarily relies on palliative approaches including oral nonsteroidal anti-inflammatory drugs (NSAIDs) and physical therapy, while effective disease-modifying drugs remain unavailable [3, 4]
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Earthleys standards are high
Furthermore, the microenvironment where PDCs function should be considered because linkers impact drug efficacy or binding affinity depending on structural differences of the linkers
This steep Ca 2+ gradient creates a strong driving force for Ca 2+ entry and is maintained by the low Ca 2+ permeability of the resting erythrocyte and high Ca 2+ -extruding capacity through a Ca 2+ ATPase and Na + /Ca 2+ exchanger in the cell membrane
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