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Despite the controversies about the expression of GLP-1R in vascular smooth muscle and endothelial cells, studies have shown that GLP-1RAs have anti-proliferative effects on these cells, and also reduced oxidative stress and increased the production of nitric oxide (NO) (137, 138)

We also conducted a subgroup analysis according to the route of ALC administration

It may help alleviate joint inflammation and discomfort

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In vitro, it upregulates extracellular matrix genes (COL1A1, elastin, decorin) while suppressing inflammatory cytokines