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The benefit of GLP-1 RAs appears to be time-dependent: in the LEADER trial, for instance, the absolute risk reduction in all-cause death became more pronounced with longer follow-up, rising from 0.3% at 1 year to 1.4% at 3 years [40]

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Additionally, some patients may qualify for clinical trials, which can provide access to new medications at reduced or no cost

This can be a vital choice when brand-name drugs are in short supply or when cost is a primary concern