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Phase 1 Trials In a first-in-human, randomized, placebo-controlled, single ascending dose, phase 1 trial in healthy participants, retatrutide demonstrated a favourable safety profile (similar to other incretin-based therapies) and early signs of efficacy with dose-dependent WL [42]

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Small human clinical studies in the published literature primarily from Russian researchers (retinitis pigmentosa, pulmonary tuberculosis)

[44,45] And because BAT can use glucose for non-shivering thermogenesis too, [46] this means that having more BAT can improve your blood sugars and lipids even when you haven't actually lost any weight yet

These issues can manifest in several ways