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Design strategies here must balance conjugation stability with the uniformity of the drug-to-antibody ratio (DAR)
The overarching principle is to treat the compound with the caution appropriate for an unapproved, under-studied substance
Standard Protocol Dosing Some protocols call for twice or three times daily dosing to create multiple GH pulses throughout the day
A few more data points are worth keeping in view because they round out the safety story
